Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation

The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions. Down regulation of CD3ζ leads to impairment of immune responses including reduced cell prolife...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Appleby, Laura J., Nausch, Norman, Heard, Francesca, Erskine, Louise, Bourke, Claire D., Midzi, Nicholas, Mduluza, Takafira, Allen, Judith E., Mutapi, Francisca
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332365/
https://ncbi.nlm.nih.gov/pubmed/25741337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00051
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