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Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug‐induced cell death in three‐dimensional matrix culture
Primary hepatocytes undergo phenotypic dedifferentiation upon isolation from liver that typically includes down regulation of uptake transporters and up regulation of efflux transporters. Culturing cells between layers of collagen in a three‐dimensional (3D) “sandwich” is reported to restore hepatic...
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Publicado no: | Physiol Rep |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Wiley Periodicals, Inc.
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4332201/ https://ncbi.nlm.nih.gov/pubmed/25524275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12198 |
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