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Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug‐induced cell death in three‐dimensional matrix culture

Primary hepatocytes undergo phenotypic dedifferentiation upon isolation from liver that typically includes down regulation of uptake transporters and up regulation of efflux transporters. Culturing cells between layers of collagen in a three‐dimensional (3D) “sandwich” is reported to restore hepatic...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Murray, John W., Han, Dennis, Wolkoff, Allan W.
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Periodicals, Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332201/
https://ncbi.nlm.nih.gov/pubmed/25524275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12198
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