Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium

Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for 10% of all ORFs, are the most frequently essential genomic components (53%...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Lluch-Senar, Maria, Delgado, Javier, Chen, Wei-Hua, Lloréns-Rico, Verónica, O'Reilly, Francis J, Wodke, Judith AH, Unal, E Besray, Yus, Eva, Martínez, Sira, Nichols, Robert J, Ferrar, Tony, Vivancos, Ana, Schmeisky, Arne, Stülke, Jörg, van Noort, Vera, Gavin, Anne-Claude, Bork, Peer, Serrano, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332154/
https://ncbi.nlm.nih.gov/pubmed/25609650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145558
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