SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence

The inactivation of plasminogen activator inhibitor-1 (PAI-1) has been shown to exert beneficial effects in age-related vascular diseases. Limited information is available on the molecular mechanisms regarding the negatively regulated expression of PAI-1 in the vascular system. In this study, we obs...

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Detaylı Bibliyografya
Yayımlandı:Aging Cell
Asıl Yazarlar: Wan, Yan-Zhen, Gao, Peng, Zhou, Shuang, Zhang, Zhu-Qin, Hao, De-Long, Lian, Li-Shan, Li, Yong-Jun, Chen, Hou-Zao, Liu, De-Pei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331759/
https://ncbi.nlm.nih.gov/pubmed/25040736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12247
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