Development and Validation of a High-Performance Liquid Chromatography–Tandem Mass Spectrometry Method for the Simultaneous Determination of Irinotecan and Its Main Metabolites in Human Plasma and Its Application in a Clinical Pharmacokinetic Study

Irinotecan is currently used in several cancer regimens mainly in colorectal cancer (CRC). This drug has a narrow therapeutic range and treatment can lead to side effects, mainly neutropenia and diarrhea, frequently requiring discontinuing or lowering the drug dose. A wide inter-individual variabili...

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Publicat a:PLoS One
Autors principals: Marangon, Elena, Posocco, Bianca, Mazzega, Elisa, Toffoli, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331511/
https://ncbi.nlm.nih.gov/pubmed/25689738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118194
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