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Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression
OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions. METHODS: Rat glomerular me...
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Published in: | PLoS One |
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Main Authors: | , , , , , , , , |
Format: | Artigo |
Language: | Inglês |
Published: |
Public Library of Science
2015
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331365/ https://ncbi.nlm.nih.gov/pubmed/25689721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117400 |
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