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Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A.

There are large increases in cellular levels of the polyamines spermidine and spermine in lymphocytes induced to transform by concanavalin A. The anti-leukemic agent methylglyoxal bis(guanylhydrazone) (MGBG) blocks synthesis of these polyamines by inhibiting S-adenosylmethionine decarboxylase. Previ...

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Detalhes bibliográficos
Main Authors: Fillingame, R H, Jorstad, C M, Morris, D R
Formato: Artigo
Idioma:Inglês
Publicado em: 1975
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC433134/
https://ncbi.nlm.nih.gov/pubmed/1060087
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