Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficacious, it is associated with multiple adverse events caused by systemic exposure to interferon. We therefore hypothesise that targeting IFN directly to the intended site of action in the liver would re...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rycroft, Daniel, Sosabowski, Jane, Coulstock, Edward, Davies, Marie, Morrey, John, Friel, Sarah, Kelly, Fiona, Hamatake, Robert, Ovečka, Milan, Prince, Rob, Goodall, Laura, Sepp, Armin, Walker, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331089/
https://ncbi.nlm.nih.gov/pubmed/25689509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117847
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