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KSHV-TK is a tyrosine kinase that disrupts focal adhesions and induces Rho-mediated cell contraction
Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associated herpesvirus (KSHV) is an extremely inefficient nucleoside kinase, when compared to TKs from related herpesviruses. We now show that KSHV-TK, in contrast to HSV1-TK, associates with the actin cytoskeleton and induces extens...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BlackWell Publishing Ltd
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331000/ https://ncbi.nlm.nih.gov/pubmed/25471072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490358 |
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