Engineered ribosomal RNA operon copy-number variants of E. coli reveal the evolutionary trade-offs shaping rRNA operon number

Ribosomal RNA (rrn) operons, characteristically present in several copies in bacterial genomes (7 in E. coli), play a central role in cellular physiology. We investigated the factors determining the optimal number of rrn operons in E. coli by constructing isogenic variants with 5–10 operons. We foun...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Gyorfy, Zsuzsanna, Draskovits, Gabor, Vernyik, Viktor, Blattner, Frederick F., Gaal, Tamas, Posfai, Gyorgy
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330394/
https://ncbi.nlm.nih.gov/pubmed/25618851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv040
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