Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4

BACKGROUND: The cytochrome P450 3A4 (CYP3A4) inhibitor clarithromycin may also inhibit liver-specific organic anion–transporting polypeptides (OATP1B1 and OATP1B3). We studied whether concurrent use of clarithromycin and a statin not metabolized by CYP3A4 was associated with an increased frequency o...

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Detalhes bibliográficos
Publicado no:CMAJ
Main Authors: Li, Daniel Q., Kim, Richard, McArthur, Eric, Fleet, Jamie L., Bailey, David G., Juurlink, David, Shariff, Salimah Z., Gomes, Tara, Mamdani, Muhammad, Gandhi, Sonja, Dixon, Stephanie, Garg, Amit X.
Formato: Artigo
Idioma:Inglês
Publicado em: 8872147 Canada Inc. 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330139/
https://ncbi.nlm.nih.gov/pubmed/25534598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/cmaj.140950
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