Solid microparticles based on chitosan or methyl-β-cyclodextrin: a first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate

We propose the formulation and characterization of solid microparticles as nasal drug delivery systems able to increase the nose-to-brain transport of deferoxamine mesylate (DFO), a neuroprotector unable to cross the blood brain barrier and inducing negative peripheral impacts. Spherical chitosan ch...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Rassu, Giovanna, Soddu, Elena, Cossu, Massimo, Brundu, Antonio, Cerri, Guido, Marchetti, Nicola, Ferraro, Luca, Regan, Raymond F., Giunchedi, Paolo, Gavini, Elisabetta, Dalpiaz, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330128/
https://ncbi.nlm.nih.gov/pubmed/25620068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.01.025
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