Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Borrelia burgdorferi, the causative agent of Lyme disease, utilizes manganese (Mn) for its various metabolic needs. We hypothesized that blocking Mn transporter could be a possible approach to inhibit metabolic activity of this pathogen and eliminate the infection. We used a combination of in silico...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Wagh, Dhananjay, Pothineni, Venkata Raveendra, Inayathullah, Mohammed, Liu, Song, Kim, Kwang-Min, Rajadas, Jayakumar
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330029/
https://ncbi.nlm.nih.gov/pubmed/25709405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S77063
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