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Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT(2) Receptor Ligands

[Image: see text] Migration of the methylene imidazole side chain in the first reported selective drug-like AT(2) receptor agonist C21/M024 (1) delivered the AT(2) receptor antagonist C38/M132 (2). We now report that the AT(2) receptor antagonist compound 4, a biphenyl derivative that is structurall...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wallinder, Charlotta, Sköld, Christian, Botros, Milad, Guimond, Marie-Odile, Hallberg, Mathias, Gallo-Payet, Nicole, Karlén, Anders, Alterman, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329586/
https://ncbi.nlm.nih.gov/pubmed/25699147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500427r
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