Conformational Restriction Leading to a Selective CB(2) Cannabinoid Receptor Agonist Orally Active Against Colitis

[Image: see text] The CB(2) cannabinoid receptor has been implicated in the regulation of intestinal inflammation. Following on from the promising activity of a series of 4-oxo-1,4-dihydroquinoline-3-carboxamide, we developed constrained analogues based on a 2H-pyrazolo[4,3-c]quinolin-3(5H)-one scaf...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: El Bakali, Jamal, Muccioli, Giulio G., Body-Malapel, Mathilde, Djouina, Madjid, Klupsch, Frédérique, Ghinet, Alina, Barczyk, Amélie, Renault, Nicolas, Chavatte, Philippe, Desreumaux, Pierre, Lambert, Didier M., Millet, Régis
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329582/
https://ncbi.nlm.nih.gov/pubmed/25699149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500439x
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