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Conformational Restriction Leading to a Selective CB(2) Cannabinoid Receptor Agonist Orally Active Against Colitis
[Image: see text] The CB(2) cannabinoid receptor has been implicated in the regulation of intestinal inflammation. Following on from the promising activity of a series of 4-oxo-1,4-dihydroquinoline-3-carboxamide, we developed constrained analogues based on a 2H-pyrazolo[4,3-c]quinolin-3(5H)-one scaf...
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| Udgivet i: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329582/ https://ncbi.nlm.nih.gov/pubmed/25699149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500439x |
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