Evolution of the oxygen sensitivity of cytochrome c oxidase subunit 4

Vertebrates possess two paralogs of cytochrome c oxidase (COX) subunit 4: a ubiquitous COX4-1 and a hypoxia-linked COX4-2. Mammalian COX4-2 is thought to have a role in relation to fine-tuning metabolism in low oxygen levels, conferred through both structural differences in the subunit protein struc...

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Udgivet i:Am J Physiol Regul Integr Comp Physiol
Main Authors: Kocha, K. M., Reilly, K., Porplycia, D. S. M., McDonald, J., Snider, T., Moyes, C. D.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Obesity, Diabetes and Energy Homeostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329467/
https://ncbi.nlm.nih.gov/pubmed/25519729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00281.2014
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