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The Structure of S. lividans Acetoacetyl-CoA Synthetase Shows a Novel Interaction Between the C-terminal Extension and the N-terminal Domain

The AMP-forming acyl-CoA synthetase enzymes catalyze a two-step reaction that involves the initial formation of an acyl adenylate that reacts in a second partial reaction to form a thioester between the acyl substrate and CoA. These enzymes utilize a Domain Alternation catalytic mechanism, whereby a...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Mitchell, Carter A., Tucker, Alex C., Escalante-Semerena, Jorge C., Gulick, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329092/
https://ncbi.nlm.nih.gov/pubmed/25488501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24738
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