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Enthalpy of hydrogen bond formation in a protein-ligand binding reaction.

Parallel measurements of the thermodynamics (free-energy, enthalpy, entropy and heat-capacity changes) of ligand binding to FK506 binding protein (FKBP-12) in H2O and D2O have been performed in an effort to probe the energetic contributions of single protein-ligand hydrogen bonds formed in the bindi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Connelly, P R, Aldape, R A, Bruzzese, F J, Chambers, S P, Fitzgibbon, M J, Fleming, M A, Itoh, S, Livingston, D J, Navia, M A, Thomson, J A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43285/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7510408/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.5.1964
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