βII-spectrin (SPTBN1) Suppresses Progression of Hepatocellular Carcinoma and Wnt Signaling via Regulation of Wnt Inhibitor Kallistatin

βII-spectrin (SPTBN1) is an adapter protein for Smad3/Smad4 complex formation during TGF-β signal transduction. Forty percent of SPTBN1(+/−) mice spontaneously develop hepatocellular carcinoma (HCC), and most cases of human HCC have significant reductions in SPTBN1 expression. In this study, we inve...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Zhi, Xiuling, Lin, Ling, Yang, Shaoxian, Bhuvaneshwar, Krithika, Wang, Hongkun, Gusev, Yuriy, Lee, Mi-Hye, Kallakury, Bhaskar, Shivapurkar, Narayan, Cahn, Katherine, Tian, Xuefei, Marshall, John L., Byers, Stephen W., He, Aiwu R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327990/
https://ncbi.nlm.nih.gov/pubmed/25307947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27558
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