GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease

The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of neuronal morphological and neurochemical phenotype and protects DA neurons from toxic damage. Numerous studies on animal...

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Udgivet i:Front Neuroanat
Main Authors: d’Anglemont de Tassigny, Xavier, Pascual, Alberto, López-Barneo, José
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327623/
https://ncbi.nlm.nih.gov/pubmed/25762899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnana.2015.00010
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