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Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16(Ink4a)
The cyclin-dependent kinase (Cdk) inhibitor p16(Ink4a) (p16) is a canonical mediator of cellular senescence and accumulates in aging tissues, where it constrains proliferation of some progenitor cells. However, whether p16 induction in tissues is sufficient to inhibit cell proliferation, mediate sen...
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| Опубликовано в: : | Aging Cell |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BlackWell Publishing Ltd
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4326901/ https://ncbi.nlm.nih.gov/pubmed/25481981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12279 |
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