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Free Fatty Acids Shift Insulin-induced Hepatocyte Proliferation towards CD95-dependent Apoptosis

Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth factor receptor (EGFR) and subsequent cell proliferation (1). Free fatty acids (FFAs) are known to induce lipoapoptosis in liver cells in a c-Jun-NH(2)-terminal kinase...

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Publicado en:J Biol Chem
Autores principales: Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326845/
https://ncbi.nlm.nih.gov/pubmed/25548285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617035
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