Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies

Formation of G protein-coupled receptors (GPCRs) into dimers and higher order oligomers represents a key mechanism in pleiotropic signaling, yet how individual protomers function within oligomers remains poorly understood. We present a super-resolution imaging approach, resolving single GPCR molecul...

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Udgivet i:J Biol Chem
Main Authors: Jonas, Kim C., Fanelli, Francesca, Huhtaniemi, Ilpo T., Hanyaloglu, Aylin C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326798/
https://ncbi.nlm.nih.gov/pubmed/25516594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622498
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