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Comprehensive massive parallel DNA sequencing strategy for the genetic diagnosis of the neuro-cardio-facio-cutaneous syndromes

Variants in 11 genes of the RAS/MAPK signaling pathway have been causally linked to the neuro-cardio-facio-cutaneous syndromes group (NCFCS). Recently, A2ML1 and RIT1 were also associated with these syndromes. Because of the genetic and clinical heterogeneity of NCFCS, it is challenging to define st...

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Библиографические подробности
Опубликовано в: :Eur J Hum Genet
Главные авторы: Justino, Ana, Dias, Patrícia, João Pina, Maria, Sousa, Sónia, Cirnes, Luís, Berta Sousa, Ana, Carlos Machado, José, Costa, José Luis
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326724/
https://ncbi.nlm.nih.gov/pubmed/24896146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2014.97
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