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Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.

Injection of frogs with beta-adrenergic catecholamines for 1-24 hr produces marked subsensitivity of the erythrocyte membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1.] to in vitro stimulation by isoproterenol. The subsensitization is specific for catecholamine stimulation,...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mukherjee, C, Caron, M G, Lefkowitz, R J
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1975
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432665/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1057183/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.5.1945
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