Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma

BACKGROUND: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression. ADAR2 activity is impaired in glioblastoma and its rescue has anti-tumoral effects. However, how ADAR2 activity...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Tomaselli, Sara, Galeano, Federica, Alon, Shahar, Raho, Susanna, Galardi, Silvia, Polito, Vinicia Assunta, Presutti, Carlo, Vincenti, Sara, Eisenberg, Eli, Locatelli, Franco, Gallo, Angela
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326501/
https://ncbi.nlm.nih.gov/pubmed/25582055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0575-z
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