Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction

Hepatocyte growth factor (HGF) has been shown to have anti-fibrotic, pro-angiogenic, and cardioprotective effects; however, it is highly unstable and expensive to manufacture, hindering its clinical translation. Recently, a HGF fragment (HGF-f), an alternative c-MET agonist, was engineered to posses...

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Publicado en:Biomaterials
Autores principales: Sonnenberg, Sonya, Rane, Aboli A., Liu, Cassie J., Rao, Nikhil, Agmon, Gillie, Suarez, Sophia, Wang, Raymond, Munoz, Adam, Bajaj, Vaibhav, Zhang, Shirley, Braden, Rebecca, Schup-Magoffin, Pamela J., Kwan, Oi Ling, DeMaria, Anthony N., Cochran, Jennifer R., Christman, Karen L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326250/
https://ncbi.nlm.nih.gov/pubmed/25662495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.12.021
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