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Computing Smallest Intervention Strategies for Multiple Metabolic Networks in a Boolean Model

This article considers the problem whereby, given two metabolic networks N(1) and N(2), a set of source compounds, and a set of target compounds, we must find the minimum set of reactions whose removal (knockout) ensures that the target compounds are not producible in N(1) but are producible in N(2)...

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Détails bibliographiques
Publié dans:J Comput Biol
Auteurs principaux: Lu, Wei, Tamura, Takeyuki, Song, Jiangning, Akutsu, Tatsuya
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326032/
https://ncbi.nlm.nih.gov/pubmed/25684199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2014.0274
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