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The Epstein-Barr Virus BamHI C Promoter Is Not Essential for B Cell Immortalization In Vitro, but It Greatly Enhances B Cell Growth Transformation

Epstein-Barr virus (EBV) infection of B cells leads to the sequential activation of two viral promoters, Wp and Cp, resulting in the expression of six EBV nuclear antigens (EBNAs) and the viral Bcl2 homologue BHRF1. The viral transactivator EBNA2 is required for this switch from Wp to Cp usage durin...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Tierney, Rosemary J., Nagra, Jasdeep, Rowe, Martin, Bell, Andrew I., Rickinson, Alan B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325715/
https://ncbi.nlm.nih.gov/pubmed/25540367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03300-14
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