The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial

OBJECTIVES: Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients under...

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Bibliographic Details
Published in:Eur J Cardiothorac Surg
Main Authors: Drury, Nigel E., Howell, Neil J., Calvert, Melanie J., Weber, Ralf J.M., Senanayake, Eshan L., Lewis, Michael E., Hyde, Jonathan A.J., Green, David H., Mascaro, Jorge G., Wilson, Ian C., Graham, Timothy R., Rooney, Stephen J., Viant, Mark R., Freemantle, Nick, Frenneaux, Michael P., Pagano, Domenico
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Adult Cardiac
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324609/
https://ncbi.nlm.nih.gov/pubmed/24948413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ejcts/ezu238
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