The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial

OBJECTIVES: Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients under...

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Detalhes bibliográficos
Publicado no:Eur J Cardiothorac Surg
Main Authors: Drury, Nigel E., Howell, Neil J., Calvert, Melanie J., Weber, Ralf J.M., Senanayake, Eshan L., Lewis, Michael E., Hyde, Jonathan A.J., Green, David H., Mascaro, Jorge G., Wilson, Ian C., Graham, Timothy R., Rooney, Stephen J., Viant, Mark R., Freemantle, Nick, Frenneaux, Michael P., Pagano, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Adult Cardiac
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324609/
https://ncbi.nlm.nih.gov/pubmed/24948413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ejcts/ezu238
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