Mitochondrial Aldehyde Dehydrogenase 2 Plays Protective Roles in Heart Failure After Myocardial Infarction via Suppression of the Cytosolic JNK/p53 Pathway in Mice

BACKGROUND: Increasing evidence suggests a critical role for mitochondrial aldehyde dehydrogenase 2 (ALDH2) in protection against cardiac injuries; however, the downstream cytosolic actions of this enzyme are largely undefined. METHODS AND RESULTS: Proteomic analysis identified a significant downreg...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Sun, Aijun, Zou, Yunzeng, Wang, Ping, Xu, Danling, Gong, Hui, Wang, Shijun, Qin, Yingjie, Zhang, Peng, Chen, Yunqin, Harada, Mutsuo, Isse, Toyoshi, Kawamoto, Toshihiro, Fan, Huizhi, Yang, Pengyuan, Akazawa, Hiroshi, Nagai, Toshio, Takano, Hiroyuki, Ping, Peipei, Komuro, Issei, Ge, Junbo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323818/
https://ncbi.nlm.nih.gov/pubmed/25237043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000779
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