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Local N-Methyl-D-Aspartate Receptor Antagonism in the Prefrontal Cortex Attenuates Spatial Cognitive Deficits Induced by Gonadectomy in Adult Male Rats

Gonadectomy in adult male rats significantly impairs spatial working memory, behavioral flexibility and other functions associated with the prefrontal cortex (PFC). However, the mechanisms through which this occurs are largely unknown. In this study, intracortical drug challenge with the selective N...

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Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Locklear, Mallory N., Bhamidipaty, Surya, Kritzer, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323667/
https://ncbi.nlm.nih.gov/pubmed/25545712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.12.032
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