Synergistic Inhibition of Tumor Necrosis Factor-Alpha-Stimulated Pro-Inflammatory Cytokine Expression in HaCaT Cells by a Combination of Rapamycin and Mycophenolic Acid

BACKGROUND: Keratinocytes release various pro-inflammatory cytokines, chemokines, and adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) in response to cytokines such as tumor necrosis factor (TNF)-α and interferon (IFN)-γ. Rapamycin and mycophenolic acid (MPA) have potent immunos...

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Bibliographische Detailangaben
Veröffentlicht in:Ann Dermatol
Hauptverfasser: Kim, Min Young, Lim, Yun Young, Kim, Hyeong Mi, Park, Young Min, Kang, Hoon, Kim, Beom Joon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323600/
https://ncbi.nlm.nih.gov/pubmed/25673929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5021/ad.2015.27.1.32
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