Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5’ splice site within Col2a1 exon 2

This study describes a new mechanism controlling the production of alternatively-spliced isoforms of type II procollagen (Col2a1) in vivo. During chondrogenesis, precursor chondrocytes predominantly produce isoforms containing alternatively-spliced exon 2 (type IIA and IID) while Col2a1 mRNA devoid...

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Publicado en:Matrix Biol
Autores principales: Hering, Thomas M., Wirthlin, Louisa, Ravindran, Soumya, McAlinden, Audrey
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323166/
https://ncbi.nlm.nih.gov/pubmed/24735995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2014.04.004
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