CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling

Human ovarian cancer is diagnosed in the late, metastatic stages but the underlying mechanisms remain poorly understood. We report a surprising functional link between CD151-α3β1 integrin complexes and the malignancy of serous-type ovarian cancer. Analyses of clinical specimens indicate that CD151 e...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Baldwin, Lauren A., Hoff, John T., Lefringhouse, Jason, Zhang, Michael, Jia, Changhe, Liu, Zeyi, Erfani, Sonia, Jin, Hongyan, Xu, Mei, She, Qing-Bai, van Nagell, John R., Wang, Chi, Chen, Li, Plattner, Rina, Kaetzel, David M., Luo, Jia, Lu, Michael, West, Dava, Liu, Chunming, Ueland, Fred R., Drapkin, Ronny, Zhou, Binhua P., Yang, Xiuwei H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322965/
https://ncbi.nlm.nih.gov/pubmed/25356755
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