The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signalling

CYLD, an ubiquitin hydrolase, has an expanding repertoire of regulatory roles in cell signalling and is dysregulated in a number of cancers. To dissect CYLD function we used a proteomics approach to identify CYLD interacting proteins and identified MIB2, an ubiquitin ligase enzyme involved in Notch...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Rajan, Neil, Elliott, Richard J.R., Smith, Alice, Sinclair, Naomi, Swift, Sally, Lord, Christopher J., Ashworth, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322962/
https://ncbi.nlm.nih.gov/pubmed/25565632
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