Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

BACKGROUND: Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) acts as an anti-inflammatory factor and has been reported to modulate TLRs in some...

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Vydáno v:BMC Cancer
Hlavní autoři: Chuffa, Luiz Gustavo A, Fioruci-Fontanelli, Beatriz A, Mendes, Leonardo O, Ferreira Seiva, Fábio R, Martinez, Marcelo, Fávaro, Wagner J, Domeniconi, Raquel F, Pinheiro, Patrícia FF, Delazari dos Santos, Lucilene, Martinez, Francisco Eduardo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322437/
https://ncbi.nlm.nih.gov/pubmed/25655081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1032-4
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