VEGF-A modulates expression of inhibitory checkpoints on CD8(+) T cells in tumors

Immune escape is a prerequisite for tumor development. To avoid the immune system, tumors develop different mechanisms, including T cell exhaustion, which is characterized by expression of immune inhibitory receptors, such as PD-1, CTLA-4, Tim-3, and a progressive loss of function. The recent develo...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Voron, Thibault, Colussi, Orianne, Marcheteau, Elie, Pernot, Simon, Nizard, Mevyn, Pointet, Anne-Laure, Latreche, Sabrina, Bergaya, Sonia, Benhamouda, Nadine, Tanchot, Corinne, Stockmann, Christian, Combe, Pierre, Berger, Anne, Zinzindohoue, Franck, Yagita, Hideo, Tartour, Eric, Taieb, Julien, Terme, Magali
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322048/
https://ncbi.nlm.nih.gov/pubmed/25601652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140559
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