The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan

AT1 receptor (AT1R) antagonists exert their antihypertensive effects by preventing the vasoconstrictive hormone AngII to bind to the AT1 receptor. It has been proposed that these biological effects are mediated through a two-step mechanism reaction. In the first step, they are incorporated in the co...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Ntountaniotis, Dimitrios, Kellici, Tahsin, Tzakos, Andreas, Kolokotroni, Pinelopi, Tselios, Theodore, Becker-Baldus, Johanna, Glaubitz, Clemens, Lin, Sonyan, Makriyannis, Alexandros, Mavromoustakos, Thomas
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321718/
https://ncbi.nlm.nih.gov/pubmed/24946142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.06.003
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