Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

The paradigm that microtubule-targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but cannot explain MTA activity in slowly growing human cancers. Many preferred cancer regimens combine a MTA with a DNA-damaging agent (DDA). We hypothesized that MTAs synergi...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Poruchynsky, Marianne S., Komlodi-Pasztor, Edina, Trostel, Shana, Wilkerson, Julia, Regairaz, Marie, Pommier, Yves, Zhang, Xu, Kumar Maity, Tapan, Robey, Robert, Burotto, Mauricio, Sackett, Dan, Guha, Udayan, Fojo, Antonio Tito
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321245/
https://ncbi.nlm.nih.gov/pubmed/25605897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416418112
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