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GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy

Autophagy is a common physiological function in all eukaryotes. The process is induced by depletion of nutrients including amino acids. GADD34 is expressed following DNA damage, ER stresses and amino acid deprivation. Here, we investigated the effects of GADD34 on autophagy and cell activation in ma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Ito, Sachiko, Tanaka, Yuriko, Oshino, Reina, Aiba, Keiko, Thanasegaran, Suganya, Nishio, Naomi, Isobe, Ken-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321179/
https://ncbi.nlm.nih.gov/pubmed/25659802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08327
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