Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

The mode of action human relevance (MOA/HR) framework increases transparency in systematically considering data on MOA for end (adverse) effects and their relevance to humans. This framework continues to evolve as experience increases in its application. Though the MOA/HR framework is not designed t...

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Detalhes bibliográficos
Publicado no:J Appl Toxicol
Main Authors: Meek, M E (Bette), Palermo, Christine M, Bachman, Ammie N, North, Colin M, Jeffrey Lewis, R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Review Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321063/
https://ncbi.nlm.nih.gov/pubmed/24777878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jat.2984
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