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Evolutionarily emerged G tracts between the polypyrimidine tract and 3′ AG are splicing silencers enriched in genes involved in cancer
BACKGROUND: The 3′ splice site (SS) at the end of pre-mRNA introns has a consensus sequence (Y)(n)NYAG for constitutive splicing of mammalian genes. Deviation from this consensus could change or interrupt the usage of the splice site leading to alternative or aberrant splicing, which could affect no...
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| Publicado no: | BMC Genomics |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4320613/ https://ncbi.nlm.nih.gov/pubmed/25523808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-1143 |
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