Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but more potent than nalidixic acid and a known inhibitor of DNA replication in E. coli. The supercoiling activity of DNA gyrase purified from nalidixic acid-resistant mutant...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gellert, Martin, Mizuuchi, Kiyoshi, O'Dea, Mary H., Itoh, Tateo, Tomizawa, Jun-Ichi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1977
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/337300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.11.4772
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