A Phase I/II Study of Bortezomib in Combination with Paclitaxel, Carboplatin and Concurrent Thoracic Radiation Therapy for Non-Small Cell Lung Cancer: NCCTG-N0321

INTRODUCTION: Despite the advances in radiation techniques and chemotherapy, survival with current platinum-based chemotherapy and concomitant thoracic radiation remains dismal. Bortezomib, a proteasome inhibitor, modulates apoptosis and cell cycle through disruption of protein degradation. The comb...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Zhao, Yujie, Foster, Nathan R., Meyers, Jeffrey P., Thomas, Sachdev P., Northfelt, Donald W., Rowland, Kendrith M., Mattar, Bassam I., Johnson, David B., Molina, Julian R., Mandrekar, Sumithra J., Schild, Steven E., Bearden, James D., Aubry, Marie-Christine, Adjei, Alex A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320011/
https://ncbi.nlm.nih.gov/pubmed/25247339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000383
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