Results of Phase II Randomized Study of Low-Dose Decitabine with or without Valproic Acid in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia

BACKGROUND: Hypomethylating agents have shown activity in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Pre-clinical and single-arm trials have suggested that adding histone deacetylase (HDAC) inhibitors may synergize the epigenetic modulation of hypomethylating agents and improve...

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Publicado en:Cancer
Autores principales: Issa, Jean Pierre, Garcia-Manero, Guillermo, Huang, Xuelin, Cortes, Jorge, Ravandi, Farhad, Jabbour, Elias, Borthakur, Gautam, Brandt, Mark, Pierce, Sherry, Kantarjian, Hagop
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320000/
https://ncbi.nlm.nih.gov/pubmed/25336333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29085
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