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Data Mining in the U.S. National Toxicology Program (NTP) Database Reveals a Potential Bias Regarding Liver Tumors in Rodents Irrespective of the Test Agent

Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances, mixtures, and multi-compounds. In such a study, mice and rats are exposed to a test agent at different dose levels for a period of two years and the incidence of neoplastic lesions is observed. Howe...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Ring, Matthias, Eskofier, Bjoern M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319901/
https://ncbi.nlm.nih.gov/pubmed/25658102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116488
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