Regression to the Mean and Predictors of MRI Disease Activity in RRMS Placebo Cohorts - Is There a Place for Baseline-to-Treatment Studies in MS?

BACKGROUND: Gadolinium-enhancing (GD+) lesions and T2 lesions are MRI outcomes for phase-2 treatment trials in relapsing-remitting Multiple Sclerosis (RRMS). Little is known about predictors of lesion development and regression-to-the-mean, which is an important aspect in early baseline-to-treatment...

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Bibliographic Details
Published in:PLoS One
Main Authors: Stellmann, Jan-Patrick, Stürner, Klarissa Hanja, Young, Kim Lea, Siemonsen, Susanne, Friede, Tim, Heesen, Christoph
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319835/
https://ncbi.nlm.nih.gov/pubmed/25659100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116559
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