MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer

Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to affect cellular signaling. Here, we demonstrate that MnSOD upregulation in cancer cells establishes a steady flow of H(2)O(2) originating fr...

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Publicado en:Nat Commun
Autores principales: Hart, Peter C., Mao, Mao, de Abreu, Andre Luelsdorf, Ansenberger-Fricano, Kristine, Ekoue, Dede N., Ganini, Douglas, Kajdacsy-Balla, Andre, Diamond, Alan M., Minshall, Richard D., Consolaro, Marcia E. L., Santos, Janine H., Bonini, Marcelo G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319569/
https://ncbi.nlm.nih.gov/pubmed/25651975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7053
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